Bone mass, density and geometry in phenylketonuria, reviewing the evidence | Evidence Summary

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DESCRIPTION

The objective of this summary is to assess the available evidence relating to PKU and bone investigating the hypothesis that GMP-based protein substitutes are beneficial for bone health. 

The aims of this review are to examine: 

  1. How bone mass and density are defined and measured 
  2. The current evidence  
  3. Factors affecting bone in PKU including dietary management 
  4. The effect of protein substitutes, including GMP 
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